Comments on: Why don’t artificial progestins work for the treatment of PMS?

Bio-identical progesterone opposes estrogen dominance where as synthetic progestins do not.

Here’s the reason why…

Sadly, too few doctors understand the distinct differences between a synthetic progestins and natural progesterone. A natural molecule such as natural progesterone has a chemical structure identical to the progesterone produced by the ovaries.

The various synthetic progestins many doctors are prescribing these days to treat PMS are often mistaken as progesterone derivatives. These patented, not-natural-to-the-body hormones carry significant side effects i.e., moodiness, depression, increased appetite, fluid retention, weight gain, acne, greasy skin and even increased cholesterol. These exacerbate the problems of PMS even further.

Because our body uses progesterone to make other steroid hormone such as testosterone and the three different types of estrogen, progesterone cream can have an enormous impact on your overall health. Treating PMS is but one example.

Synthetic progestins, however, are what is termed a ‘dead-end’ hormone. Unlike progesterone, your body cannot use a progestin to manufacture any other steroid hormones that your body might need (this is why progesterone is a hormone balance and modulator).

Only natural progesterone can turn ‘on’ the progesterone receptor, as a key can unlock the door. A synthetic progestin, therefore, will not have the same beneficial effect as does human-identical progesterone.

At this time, the medical fraternity do not necessarily recognise that PMS is related to progesterone deficiency as brought about by anovulatary cycles or insufficient progesterone output at ovulation (our diagram in this section demonstrates PMS in relation to lack of ovulation).

Many women report to us how surprised they are at the irregularity of their ovulation until they become tuned into this factor. They assumed regular periods indicated ovulation, which may not necessarily be the case!

Does artificial progestin therapy do the same as progesterone therapy? I am taking a progestogen to control PMS symptoms such as irritability and depression. Is it the same thing?

Again, it gets back to the lack of understanding of the distinction and difference between synthetic and natural hormones.

Depression and PMS syndrome (PMS) can be caused or aggravated by synthetic progestins such as is found in Provera. If it is not helping you and you are experiencing side effects, we suggest you switch to natural progesterone because it is less likely to cause mood disorders like its synthetic ‘cousin’ – progestin.

You can be forgiven for mistaking progestin for progesterone and vice versa. But there really is a big difference … and your body knows it.

So if you are experiencing side effects taking oral progestin tablets, why not try topical human-identical progesterone cream that you rub onto your skin. See if it doesn’t alleviate your mood swings and PMS. If you’re still feeling irritable, glum, and depressed after 4 months on progesterone and your moods haven’t elevated and enhanced with a sense of wellbeing you need to explore the possibility that your depression may have other origins requiring further investigation.

Interestingly, some women have adopted other strategies such as magnesium, St Johns Wort, B complex and naturopathic lithium which has proved very successful in conjunction with natural progesterone, eliminating the need to resort to anti-depressant medication. Whilst other women, some short term, have needed to go on ” to support them along with their progesterone.

Is my combination patch ‘natural’? My doctor has prescribed it to treat PMS.

There is an estrogen and progestin combination patch now on the market. This does not contain natural progesterone but it does contain natural or bioidentical estrogen.

If you are suffering side effects from synthetic hormone replacement you may wish to investigate alternative forms of natural hormone replacement therapy.

We suggest you ask your doctor to order a saliva assay / blood work to determine your hormone profile when introducing combination hormone therapy to treat PMS.

Given that there is suggestion PMS is perhaps an estrogen dominance disorder, you may not require additional estrogen in your body.

Note, it is the way these hormones are delivered that is patented here. Certainly, the patch does contain ‘natural’ estrogen however it does not contain ‘natural’ progesterone as women are being led to believe. They contain synthetic progestagins. There is NO patch to date that contains natural progesterone, possibly due in part because research has shown that natural progesterone is most effectively absorbed and utilised by the human body when applied as a cream.

Drug companies marketing these patches indicate to women that their products are derived from natural substances such as plants and modified to copy the estrogen produced by the female human ovary. Technically this is correct, but their constant reference to ‘natural’ is a play on words and implies progestagens and progesterone are interchangeable. One would have to understand the distinction in order to pick this up. At a time when women are becoming aware of progesterone, perhaps it’s no accident drug companies are interchanging words to catch you attention.

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